4 hydroxyacetophenone manufacturers

4-Hydroxyacetophenone (CAS No. 99-93-4) is a versatile organic synthesis intermediate. In the cosmetic industry, it serves as a multi-functional booster, enhancing the efficacy of preservatives and acting as a soothing agent and antioxidant. In the pharmaceutical sector, it is a key raw material for synthesizing drugs like Choleretics and other organic compounds. It is also utilized as a flavor stabilizer in food-grade applications and a polymerization inhibitor in chemical manufacturing.

Buyers should demand a purity level of ≥99.0% (determined by HPLC) for high-end cosmetic or pharmaceutical grades. Key physical properties to verify include a melting point between 107°C and 110°C and a moisture content (LOD) of <0.5%. For cosmetic applications, ensure the product is a white crystalline powder with low odor intensity to avoid affecting the final formulation's sensory profile.

Suppliers must provide a comprehensive Material Safety Data Sheet (MSDS/SDS) compliant with GHS standards. For the EU market, REACH registration is essential. If intended for cosmetics, verify compliance with INCI (International Nomenclature Cosmetic Ingredient) standards. Ensure the manufacturer holds ISO 9001 (Quality Management) and ISO 14001 (Environmental Management) certifications to guarantee batch-to-batch consistency and sustainable production.

The product is stable under normal conditions but must be stored in a cool, dry, and well-ventilated warehouse. It should be kept in tightly sealed containers away from strong oxidizing agents and strong bases. Because it is sensitive to light and moisture, UV-protected packaging (such as fiber drums with PE inner bags) is recommended to prevent degradation during long-term storage.

The primary risks include quality disparity between samples and bulk orders and regulatory seizure due to improper labeling. To mitigate these, always request a Pre-Shipment Inspection (PSI) and a COA (Certificate of Analysis) for every batch. Use Made-in-China.com’s Secured Trading services to ensure payment is only released upon verification of shipping documents and quality compliance.

Focus on Tiered Pricing based on volume; for 4-Hydroxyacetophenone, price breaks usually occur at 500kg, 1mt, and 5mt levels. Negotiate for free samples (50-100g) for lab testing before committing to a bulk purchase. Inquire about lead times, which typically range from 7 to 15 days for standard stock, and confirm if the supplier can provide customized packaging (e.g., 25kg drums vs. 1mt big bags).

While 4-Hydroxyacetophenone is generally not classified as a highly dangerous good for transport (check specific local regulations), it must be accompanied by a Non-Hazardous Chemical Declaration to facilitate smooth customs clearance. Ensure the use of pallets with shrink-wrap for sea freight to prevent moisture ingress. For urgent small batches, air freight is viable, but ensure the packaging meets IATA standards.

Prioritize Audited Suppliers on Made-in-China.com who have undergone on-site factory inspections. Verify the supplier's Business License and their history of exporting to your specific region. Utilize Escrow-based payment terms to protect your capital against non-delivery or sub-standard goods, and always define dispute resolution protocols in the initial Proforma Invoice (PI).