When selecting a system, prioritize HEPA H13 or H14 grade filters, which are medical-grade and capable of capturing 99.97% to 99.99% of particles as small as 0.3 microns. For industrial or high-traffic environments, ensure the unit includes a large-capacity Activated Carbon filter to neutralize Volatile Organic Compounds (VOCs) and odors. If the application requires sterilization, look for integrated UV-C Germicidal Lamps or Plasma Ionization technology, but verify they are Ozone-free (UL 867 or UL 2998 certified) to ensure occupant safety.