When evaluating M12 lenses, you must prioritize Optical Resolution (Megapixel rating) to match your sensor's capability. Key parameters include the Focal Length (mm), which determines the field of view, and the Aperture (F-number), which affects low-light performance. Ensure the Image Circle size (e.g., 1/2.3", 1/3") is compatible with your CMOS sensor to avoid vignetting. Additionally, verify the Lens Construction (e.g., 6G for six glass elements) as glass offers better thermal stability than plastic (P) in industrial environments.