The price is primarily driven by the chipset generation (e.g., X670, Z790) and the PCIe lane configuration. For high-end Nvidia GPUs, motherboards must support PCIe 5.0 or 4.0 to ensure maximum bandwidth. Additionally, the Power Phase Design (VRM) significantly impacts cost; high-performance boards require robust VRMs to maintain stability during intensive GPU tasks like AI rendering or gaming. Always verify SLI/NVLink support if the application requires multi-GPU configurations, as this adds a premium to the price.