Suppliers must comply with REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) for the European market to ensure no harmful substances like lead or phthalates are present. For the US market, ASTM F2413 is relevant if sourcing safety sneakers, and CPSIA compliance is mandatory for children's footwear. Additionally, look for manufacturers with ISO 9001 (Quality Management) and BSCI (Business Social Compliance Initiative) audits to ensure ethical production and consistent quality control.